تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
مكونات الهواء تؤثر على تكوين الثرومبين في الناس الأصحاء. مشروع RAPTES
Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project
 
الموضوع : علوم البيئة 
لغة الوثيقة : الانجليزية 
المستخلص : ABSTRACT Objectives Increases in ambient particulate matter (PM) have been associated with an elevated risk of stroke, myocardial ischaemia and coronary heart disease, with activation of blood coagulation likely playing an important role. PM-mediated activation of two major activation pathways of coagulation provides a potential mechanism for the observed association between PM and cardiovascular disease. However, it remains unclear which specific characteristics and components of air pollution are responsible. Methods In order to investigate those characteristics and components, we semiexperimentally exposed healthy adult volunteers at five different locations with increased contrasts and reduced correlations among PM characteristics. Volunteers were exposed for 5 h, exercising intermittently, 3–7 times at different sites from March to October 2009. On site, we measured PM mass and number concentration, its oxidative potential (OP), content of elemental/organic carbon, trace metals, sulphate, nitrate and gaseous pollutants (ozone, nitrogen oxides). Before and 2 and 18 h after exposure we sampled blood from the participants and measured thrombin generation using the calibrated automated thrombogram. Results We found that thrombin generation increases in the intrinsic (FXII-mediated) blood coagulation pathway in relation to ambient air pollution exposure. The associations with NO2, nitrate and sulphate were consistent and robust, insensitive to adjustment for other pollutants. The associations with tissue factor-mediated thrombogenicity were not very consistent. Conclusions Ex vivo thrombin generation was associated with exposure to NO2, nitrate and sulphate, but not PM mass, PM OP or other measured air pollutants. 
ردمد : 1351-0711 
اسم الدورية : OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 
المجلد : 70 
العدد : 5 
سنة النشر : 1434 هـ
2013 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, June 4, 2013 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Maciej StrakStrak, Maciej باحث  
Gerard HoekHoek, Gerard باحث  
Maaike SteenhofSteenhof, Maaike باحث  
Evren KilincKilinc, Evren باحث  
Krystal J. GodriGodri, Krystal J. باحث  
Ilse GosensGosens, Ilse باحث  
Ian S MudwayMudway, Ian S باحث  
Rene van Oerlevan Oerle, Rene باحث  
Henri M. H SpronkSpronk, Henri M. H باحث  
Flemming R CasseeCassee, Flemming R باحث  
Frank J KellyKelly, Frank J باحث  
Roy M HarrisonHarrison, Roy M باحث  
Bert BrunekreefBrunekreef, Bert باحث  
Erik LebretLebret, Erik باحث  
Nicole A. H JanssenJanssen, Nicole A. H باحث nicole.janssen@rivm.nl

الملفات

اسم الملفالنوعالوصف
 35618.pdf pdfComponents of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project

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