تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
التعرض لتلوث الهواء يؤثر على عدد دوران كرات الدم البضاء فى الحالات اللصحية: دور تركيب حبيبات الغبارو الإجهاد التأكسدى والملوثات الغازية. مشروع الرابتس
Air pollution exposure affects circulating white blood cell counts in healthy subjects: the role of particle composition, oxidative potential and gaseous pollutants - the RAPTES project
 
الموضوع : علوم البيئة 
لغة الوثيقة : الانجليزية 
المستخلص : Studies have linked air pollution exposure to cardiovascular health effects, but it is not clear which components drive these effects. We examined the associations between air pollution exposure and circulating white blood cell (WBC) counts in humans. To investigate independent contributions of particulate matter (PM) characteristics, we exposed 31 healthy volunteers at five locations with high contrast and reduced correlations amongst pollutant components: two traffic sites, an underground train station, a farm and an urban background site. Each volunteer visited at least three sites and was exposed for 5 h with intermittent exercise. Exposure measurements on-site included PM mass and number concentration, oxidative potential (OP), elemental- and organic carbon, metals, O-3 and NO2. Total and differential WBC counts were performed on blood collected before and 2 and 18 h postexposure (PE). Changes in total WBC counts (2 and 18 h PE), number of neutrophils (2 h PE) and monocytes (18 h PE) were positively associated with PM characteristics that were high at the underground site. These time-dependent changes reflect an inflammatory response, but the characteristic driving this effect could not be isolated. Negative associations were observed for NO2 with lymphocytes and eosinophils. These associations were robust and did not change after adjustment for a large suite of PM characteristics, suggesting an independent effect of NO2. We conclude that short-term air pollution exposure at real-world locations can induce changes in WBC counts in healthy subjects. Future studies should indicate if air pollution exposure-induced changes in blood cell counts results in adverse cardiovascular effects in susceptible individuals. 
ردمد : 0895-8378 
اسم الدورية : Inhalation Toxicology 
المجلد : 26 
العدد : 3 
سنة النشر : 1435 هـ
2014 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Thursday, April 3, 2014 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Maaike SteenhofSteenhof, Maaike باحث  
Nicole A. H. JanssenJanssen, Nicole A. H. باحث  
Maciej StrakStrak, Maciej باحث  
Gerard HoekHoek, Gerard باحث  
Ilse GosensGosens, Ilse باحث  
Ian S. MudwayMudway, Ian S. باحث  
Frank J. KellyKelly, Frank J. باحث  
Roy M. HarrisonHarrison, Roy M. باحث  
Raymond H. H. PietersPieters, Raymond H. H. باحث  
Flemming R. CasseeCassee, Flemming R. باحث  
Bert BrunekreefBrunekreef, Bert باحث b.brunekreef@uu.nl

الملفات

اسم الملفالنوعالوصف
 36773.pdf pdfAir pollution exposure affects circulating white blood cell counts in healthy subjects: the role of particle composition, oxidative potential and gaseous pollutants – the RAPTES project

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